Serum NMDA Receptor Antibodies Do Not Predict Treatment Response in a Sample of People With First-Episode Psychosis
نویسندگان
چکیده
Autoimmune encephalitis is a rare but potentially life-changing illness in which antibodies damage healthy brain cells. It can present with wide range of neurological and psychiatric symptoms, from seizures autonomic instability to depression anxiety (1). also mimic schizophrenia other psychotic illnesses Since the 1950s, an array causative autoantibodies has been identified (1), NMDA receptor (NMDAR) antibody type most consistently associated psychosis (2).
منابع مشابه
Substance use in a population-based clinic sample of people with first-episode psychosis.
BACKGROUND Substance use is implicated in the cause and course of psychosis. AIMS To characterise substance and alcohol use in an epidemiologically representative treatment sample of people experiencing a first psychotic episode in south Cambridgeshire. METHOD Current and lifetime substance use was recorded for 123 consecutive referrals to a specialist early intervention service. Substance ...
متن کاملCortisol and Inflammatory Biomarkers Predict Poor Treatment Response in First Episode Psychosis
BACKGROUND Cortisol and inflammatory markers have been increasingly reported as abnormal at psychosis onset. The main aim of our study was to investigate the ability of these biomarkers to predict treatment response at 12 weeks follow-up in first episode psychosis. METHODS In a longitudinal study, we collected saliva and blood samples in 68 first episode psychosis patients (and 57 controls) a...
متن کاملAnti-NMDA receptor antibodies in patients with a first episode of schizophrenia
BACKGROUND Encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDA-R) is classified as an autoimmune disorder with psychotic symptoms, which are frequently dominant. However, it remains unclear how frequently NMDA-R antibodies lead to a condition that mimics psychosis and first-episode schizophrenia. In our work, we investigated the presence of antibodies against NMDA-R in pati...
متن کاملSexual dysfunction in people with prodromal or first-episode psychosis.
BACKGROUND Sexual dysfunction is common in psychotic disorder but it is not clear whether it is intrinsic to the development of the illness or secondary to other factors. AIMS To compare sexual function in people at ultra-high risk (UHR) of a psychotic disorder, patients with first-episode psychosis predominantly taking antipsychotic drugs and healthy volunteers. METHOD Sexual function was ...
متن کاملHistory of alcohol abuse reduces response to antipsychotics in people with first episode psychosis.
Patients: 262 people aged 16–40 years, with schizophrenia, schizophreniform or schizoaffective disorder (DSM-IV), presenting with first episode psychosis. Participants scored >4 on the Positive and Negative Syndrome Scale (PANSS) and had a Clinical Global Impression (CGI) severity score >4. Exclusions: substance use in previous month, received antipsychotic drugs for more than 16 weeks, unstabl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2021
ISSN: ['1873-2402', '0006-3223']
DOI: https://doi.org/10.1016/j.biopsych.2021.04.017